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Scientists funded by the US government have developed a way to make pox viruses
incredibly deadly. Ostensibly, this research is being conducted as part of the
plan to fight possible bio-terror attacks. The new virus kills all mice even if
they have been given antiviral drugs along with a vaccine that would normally
protect the victim from death. Mark Buller of the University of St. Louis has
managed to modify mousepox, rabbitpox, and cowpox viruses so that they
are deadly to vaccinated mice nearly 100% of the time through the introduction
of an immunosuppressant protein called Interleukin-4 (IL-4). The modified pox
viruses eliminate the immune system’s cell-mediated response. They are now
immune to the antiviral drug Cidofovir, known to be the last line of defense in
treating resistant viruses.
Scientists at the Australian National University in Canberra made the original
discovery by accident, though their virus only killed off sixty percent of infected
mice. As a side effect of introducing IL-4 into pox viruses, the virus becomes
species specific and non-communicable, though no one is quite sure why this
is the case.
The implications of this discovery and their disclosure are staggering. IL-4
is a protein common in genetic research and as such is available on the Internet
for as low as sixty dollars. Furthermore the procedure is simple, something
that a biology graduate student should be able to manage without trouble. The
bio-terrorist potential for an IL-4 modified pox virus that infects humans is
extraordinary. Like anthrax, only those who come into contact with the virus
itself would become infected. The virus would not spread and infect the attackers.
Neither would it require state of the art scientific facilities to create such
a virus. Buller and his team are currently working on a drug to resist the new
viruses, but have so far been unsuccessful in making it 100% effective.
FOR MORE INFORMATION ON THIS STORY, PLEASE GO TO:
The New Scientist website at
http://www.newscientist.com/news/news.jsp?id=ns99994318
or the Howard Hughes Medical Institute at
http://www.hhmi.org/news/karupiah.html
ALSO SEE A PREVIOUS LOOKING GLASS NEWS STORY:
The Mysterious
Deaths of Top Microbiologists
