The first BSE case was identified in 1986 in Britain. The first human case of
vCJD was diagnosed in 1995, also in Britain, which has borne the brunt of the
vCJD epidemic, with more than 150 human cases.
TORONTO -- A leading medical journal has published a disturbing theory about the
possible origins of bovine spongiform encephalopathy, suggesting that mad-cow
disease may have developed because human remains were fed to British cattle in
the 1960s and 1970s.
Canada's leading expert on transmissible spongiform encephalopathies says the
unsettling hypothesis presented this week in The Lancet might be accurate. "All
I can say at this point is it's plausible. It's not out to lunch," Dr.
Neil Cashman said from Vancouver, where he teaches in the department of neurology
at the University of British Columbia. "But it's also not clear whether
this hypothesis is true, or even if this hypothesis can be tested."
It had previously been thought the brain-wasting disease passed to cattle through
remains of sheep infected with scrapie (the sheep equivalent of BSE) that were
added to cattle feed. The theory continued that humans who ate infected beef
developed a human form of BSE. It became known as variant Creutzfeldt-Jakob
disease or vCJD, to differentiate it from the classic human forms of the disease,
which can occur sporadically or run in families.
But the British team suggests a reverse scenario: The remains of humans infected
with classic CJD were fed to cattle, which became ill with a bovine version
of the human disease, known as BSE or mad-cow disease. The remains of the animals
would have been rendered and mixed into new batches of feed, infecting more
animals. Eventually, a new version of the disease, vCJD, passed back into humans.
Authors Alan and Nancy Colchester admit that their hypothesis is based on circumstantial
evidence. "We do not claim that our theory is proved, but it unquestionably
warrants further investigation," they wrote. The pair notes that hundreds
of thousands of tonnes of mammalian remains were imported to Britain for use
in fertilizer and animal feed during the 1960s and '70s. Nearly 50-per-cent
was from countries of the Indian subcontinent.
"In India and Pakistan, gathering large bones and carcasses from the land
and from rivers has long been an important local trade for peasants," the
Colchesters say in their article. "Collectors encounter considerable quantities
of human, as well as animal remains, as a result of religious customs."
Hindu doctrine instructs that bodies should be cremated and the remains deposited
in a river, preferably the legendary Ganges. Because of the cost of a full cremation,
many corpses are partially burned, then deposited in a river.
Based on standard rates of CJD infection, the authors speculate that a portion
of the human remains that made their way into animal feed in Britain would have
contained the infectious prions (misformed proteins) that cause transmissible
spongiform encephalopathies. (A Canadian government spokesman said there is
no evidence animal products containing human remains would have found their
Two neurologists from India's National Institute of Mental Health and Neurosciences
in Bangalore challenged the controversial hypothesis in a commentary that accompanies
the article, arguing that it is not clear that putrefied human remains would
Susarla Shankar and P. Satishchandra also argue that any infectious material
would have been heavily diluted, first by the other remains, then by the other
ingredients of the animal feed. "Scientists must proceed cautiously when
hypothesizing about a disease that has such wide geographic, cultural and religious
implications," they warn. "Facts to support or refute their hypothesis
now need to be gathered with urgency and great care."
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